Endocrine Abstracts

Introduction: Experimental studies suggest that a circulating protein called TRAIL (TNF-related apoptosis-inducing ligand) has the potential to treat type 2 diabetes mellitus (T2DM). We have recently demonstrated that TRAIL delivery ameliorates T2DM in the high-fat diet-fed mouse. This study aimed at evaluating whether TRAIL had the potential to treat not only T2DM but also diabetic nephropathy.Methods/design: Based on this background, 15 male db/H mice ...

Introduction: Recent studies suggest that a circulating protein called TRAIL (TNF-related apoptosis-inducing ligand) may have an important role in the treatment of type 2 diabetes mellitus (T2DM). It has been shown that TRAIL deficiency worsens T2DM and that TRAIL delivery, when it is given before disease onset, slows down T2DM development. This study aimed at evaluating whether TRAIL had the potential not only to prevent, but also to treat T2DM.Methods/...